Amoxicillin

Serum sickness reactions, erythematous maculopapular rash, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis and urticaria have been reported.

Association with Clarithromycin and Lansoprazole: In clinical trials using combination therapy with amoxicillin and clarithromycin and lansoprazole, and amoxicillin plus lansoprazole, no adverse reactions peculiar to these drug combinations were observed. Adverse reactions that occurred were limited to those already reported with amoxicillin, clarithromycin, or lansoprazole.

Triple therapy: Amoxicillin / Clarithromycin / Lansoprazole The most frequently reported adverse reactions in patients who received triple therapy were diarrhea (7%), headache (6%) and taste perversion (5%). No treatment side effects were observed at significantly higher rates with triple therapy than dual therapy regime.

Dual Therapy: Amoxicillin / Lansoprazole The most frequently reported adverse reactions in patients who received amoxicillin three times a day, three times a day, lansoprazole dual therapy were diarrhea (8%) and headache (7%). No treatment side effects were observed at significantly higher rates with amoxicillin three times a day, three times daily dual therapy of lansoprazole lansoprazole alone.

Liver: A moderate rise in AST (SGOT) and / or ALT (SGPT) have been reported, but the importance of this observation is unknown. Hepatic dysfunction, including cholestatic jaundice, hepatic cholestasis and acute cytolytic hepatitis have been reported.

Renal impairment: The crystalluria has also been reported.

Hemic and lymphatic system: anemia, including hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia and agranulocytosis have been reported during treatment with penicillin. These reactions are usually reversible after discontinuation of therapy and are believed to be hypersensitivity phenomena.

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